ZHANG Min, WANG Lu, WANG Hong-Wei, PAN Xin, PAN Wei, QI Zhong-Tian*
( Department of Microbiology, Second Military Medical University, Shanghai 200433, China )
Abstract
Vascular endothelial cell growth inhibitor (VEGI) is
a novel cytokine which belongs to the TNF superfamily. It can inhibit the
proliferation of endothelial cells and neovascularization. However, little
is known about the structure-function relationship of VEGI. In order to study
the effect of the N-terminus of VEGI on biological properties, the sequence
alignment among VEGI and TNF superfamily members based on structure knowledge
was done, and then two truncated forms of VEGI were constructed, in which
43 and 51 amino acids from N-terminus were deleted and named VEGI
Key words VEGI; expression; endothelial cell; mutants; biological activity
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